Working for regional vs major airlines always comes with a wide gap in the paycheck. Surely, with regional airlines, the flight hours are less and you get to stay and commute from your home while the major airlines provide you with the opportunity to explore the world.
The captain and the First Officer also have a distinctive difference in their salary amount.
The amount of time you have been working with particular airlines does affect your paycheck. So yeah, if you are at a good place then go for the long haul and make it good in numbers too.
The minimum number of monthly hours varies from 50-80 depending on the type of airlines you work for and hence the salary.